Bicuspid Aortic Valve (BAV) is a highly heritable congenital heart defect.The low frequency of BAV (1% of general population) limits our ability to perform genome-wide association studies.We present the application of four a priori SNP selection techniques, reducing the Skin multiple-testing penalty by restricting analysis to SNPs relevant to BAV i
Startle habituation is a type of implicit and automatic emotion regulation.Diminished startle habituation is linked to several psychiatric or neurological disorders.Most previous studies quantified startle habituation by assessing skin conductance response, eye-blink reflex, or motor response.The habituation of parasympathetic-mediated heart rate r
Diverse physiology relies on receptor and transporter protein down-regulation and degradation mediated by ESCRTs.Loss-of-function mutations in human ESCRT genes linked to cancers and neurological disorders are thought to block this process.However, when homologous mutations are introduced into model organisms, cells thrive and degradation persists,
BackgroundTraditional gender roles (GRs) have a considerable influence on relationships among couples.These can lead to negative health effects in women; however, their impact on intimate partner violence (IPV) has been less explored, especially among younger women.ObjectiveTo explore the association between traditional GRs and several indicators o